Many users complained that the GTA IV patch has, trough the memory offsets tweaked by the patch, broken the ASI support and rendered the mods unusable. However, some users have already found and posted some useful workarounds.

Bear in mind that the mods launched prior to the patch might have to be recompiled, so you’ll probably have to have some basic knowledge on such operations.

So, if you’re serious about keeping your mods, you can find detailed instructions here.