At Sony's E3 press conference, Konami's Hideo Kojima told that the new Metal Gear Solid 4: Guns of the Patriots will be a PlayStation 3 Exclusive.
Kojima also said that this will be the last game in the series. With this sequel Snake's story will end, and also this will be Hideo Kojima's last stand, but he told the same thing after the third sequel, who knows.
This was also the announcement that the game will be delayed for 2008. You can check out the E3 trailer here, and Hideo Kojima's speech here. And here are the screenshots.