Breton's comments came after meeting Apple's CEO Tim Cook in Brussels.
"The next job for Apple and other Big Tech, under the Digital Markets Act is to open up its gates to competitors," Breton told Reuters.
"Be it the electronic wallet, browsers or app stores, consumers using an Apple iPhone should be able to benefit from competitive services by a range of providers," he said.
The newly adopted DMA sets out a list of dos and don'ts for Apple and other tech companies to abide by to increase competition.
Breton also took aim at Apple's arguments that security and privacy issues are the reasons why it has a closed ecosystem.
"EU regulation fosters innovation, without compromising on security and privacy," he said.
Cook was apparently speechless, or at least he didn't say anything to the press.