It comes as Beijing's regulatory crackdown on the country's tech sector in the past few months has slammed the valuations of Chinese tech giants Tencent and Alibaba.
TSMC, a major supplier to Apple, overtook Tencent earlier in August. The Taiwanese chipmaker is now sitting at the top spot by market capitalization -- among Asia firms -- at more than $538 billion, according to data from Refinitiv Eikon as of Wednesday morning during Asia hours.
Tencent sat in second place, with a market capitalization of more than $536 billion while Alibaba was a distant third at about $472 billion.
The market capitalisations of both Tencent and Alibaba were hit again on Tuesday -- losing more than $20 billion each -- after China's market regulator issued draft rules aimed at stopping unfair competition on the internet.
Meanwhile chipmaker TSMC has gotten a boost as the world faces a global semiconductor shortage driven by supply chain disruptions due to the pandemic, along with a surge in demand from industries such as automobiles and data centres.
Responding to the shortage, TSMC said earlier this year it plans to invest $100 billion over the next three years to increase capacity.